The Synaptic Scaling Literature: A Systematic Review of Methodologies and Quality of Reporting.

ABSTRACT: The maintenance of the excitability of neurons and circuits is a fundamental process for healthy brain functions. One of the main homeostatic mechanisms responsible for such regulation is synaptic scaling. While this type of plasticity is well-characterized through a robust body of literature, there are no systematic evaluations of the methodological and reporting features from these studies. Our review yielded 168 articles directly investigating synaptic scaling mechanisms, which display relatively high impact, with a median impact factor of 7.76 for the publishing journals. Our methodological analysis identified that 86% of the articles made use of inhibitory interventions to induce synaptic scaling, while only 41% of those studies contain excitatory manipulations. To verify the effects

SUBMITTER: Moulin TC 

PROVIDER: S-EPMC7309364 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature