Ontology highlight
ABSTRACT:
SUBMITTER: Lang FM
PROVIDER: S-EPMC7309428 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Lang Frederick M FM Lee Kevin M-C KM Teijaro John R JR Becher Burkhard B Hamilton John A JA
Nature reviews. Immunology 20200623 8
Therapeutics against coronavirus disease 2019 (COVID-19) are urgently needed. Granulocyte-macrophage colony-stimulating factor (GM-CSF), a myelopoietic growth factor and pro-inflammatory cytokine, plays a critical role in alveolar macrophage homeostasis, lung inflammation and immunological disease. Both administration and inhibition of GM-CSF are currently being therapeutically tested in COVID-19 clinical trials. This Perspective discusses the pleiotropic biology of GM-CSF and the scientific mer ...[more]