Dataset Information

Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women.

ABSTRACT:

Aim

To investigate markers of systemic inflammation in pre- and postmenopausal women and identify possible predictors of systemic inflammation with menopause.

Methods

Cross-sectional study of 69 healthy women between 45- and 60 years. Blood samples were collected to assess leukocyte subsets and plasma cytokines. MRI and DXA scans were performed to assess body composition. Through uni- and multivariate analyses, follicle-stimulating hormone (FSH), visceral fat mass and age were evaluated as predictors of systemic inflammation in relation to menopause.

Results

Postmenopausal women tended to have higher leukocyte counts (5.4 x109 vs. 4.9 x109 cells/l, p = 0.05) reflected in increased total lymphocytes (1.8 x109 vs. 1.6 x109 cells/l, p = 0.01) and monocytes (0.5 x109 vs. 0.4 x109 cells/l, p = 0.02), compared to premenopausal women. Increased visceral fat mass was a strong predictor of high leukocyte subsets. Postmenopausal women had higher plasma TNF-? (2.24 vs. 1.91 pg/ml, p = 0.01) and IL-6 (0.45 vs. 0.33 pg/ml, p = 0.004) compared to premenopausal women and high FSH was a significant predictor of increased plasma TNF-?, IL-1? and IL-6. Menopause was further associated with increased T-cells (1,336 vs. 1,128 cells/?l, p = 0.04) reflected in significantly higher counts of exhausted-, senescent-, and memory CD4+ T-cell subsets.

Conclusions

Menopause is associated with increased systemic inflammation as well as exhausted- and senescent T-cells. We suggest, that both increased visceral fat mass and declining sex hormone levels might contribute to postmenopausal systemic inflammation and calls for further large-scale studies to confirm these findings.

SUBMITTER: Abildgaard J

PROVIDER: S-EPMC7310708 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women.

Abildgaard Julie J Tingstedt Jeanette J Zhao Yanan Y Hartling Hans Jakob HJ Pedersen Anette Tønnes AT Lindegaard Birgitte B Dam Nielsen Susanne S

PloS one 20200623 6

<h4>Aim</h4>To investigate markers of systemic inflammation in pre- and postmenopausal women and identify possible predictors of systemic inflammation with menopause.<h4>Methods</h4>Cross-sectional study of 69 healthy women between 45- and 60 years. Blood samples were collected to assess leukocyte subsets and plasma cytokines. MRI and DXA scans were performed to assess body composition. Through uni- and multivariate analyses, follicle-stimulating hormone (FSH), visceral fat mass and age were eva ...[more]

PMID: 32574226

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Dataset Information

Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women.

Aim

Methods

Results

Conclusions

Publications

Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women.

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