Dataset Information

Risk of recurrent corneal erosion in patients with diabetes mellitus in Taiwan: a population-based cohort study.

ABSTRACT:

Objective

To investigate the risk of recurrent corneal erosion (RCE) in patients with diabetes mellitus (DM).

Design, setting and participants

This retrospective, nationwide, matched cohort study included 239?854 patients with DM recruited between 2003 and 2005 from the Longitudinal Cohort of Diabetes Patients database. The control group included the same number of age-matched and sex-matched patients without DM selected from the Taiwan Longitudinal Health Insurance Database, 2000. Data for each patient were collected from the index date until December 2013.

Main outcomes and measures

The incidence and risk of RCE were compared between the two groups. Cox proportional hazards regression was used to calculate the HR for RCE after adjustment for potential confounders. The cumulative RCE incidence rate was calculated using Kaplan-Meier analysis.

Results

In total, 1236 patients with DM and 884 controls developed RCE during the follow-up period, resulting in an incidence rate of RCE in patients with DM (5.87/10 000 person-years (PY)) higher than that in the controls (4.23/10 000 PY). After adjustment for potential confounders, including hypertension, hyperlipidaemia, chronic renal disease and keratoconjunctivitis sicca, patients with DM were 1.35 times (95%?CI, 1.24 to 1.48) more likely to develop RCE than the total sample cohort.

Conclusions

DM increases the risk of RCE, which is an interdisciplinary issue. Therefore, close collaboration between endocrinologists and ophthalmologists is important in managing RCE following DM.

SUBMITTER: Jan RL

PROVIDER: S-EPMC7311018 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Publications

Risk of recurrent corneal erosion in patients with diabetes mellitus in Taiwan: a population-based cohort study.

Jan Ren-Long RL Tai Ming-Cheng MC Ho Chung-Han CH Chu Chin-Chen CC Wang Jhi-Joung JJ Tseng Sung-Huei SH Chang Yuh-Shin YS

BMJ open 20200621 6

<h4>Objective</h4>To investigate the risk of recurrent corneal erosion (RCE) in patients with diabetes mellitus (DM).<h4>Design, setting and participants</h4>This retrospective, nationwide, matched cohort study included 239 854 patients with DM recruited between 2003 and 2005 from the Longitudinal Cohort of Diabetes Patients database. The control group included the same number of age-matched and sex-matched patients without DM selected from the Taiwan Longitudinal Health Insurance Database, 2000 ...[more]

PMID: 32565466

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Project description:BackgroundBeing overweight is an important risk factor for Gestational Diabetes Mellitus (GDM), but the underlying mechanisms are not understood. Weight change between pregnancies has been suggested to be an independent mechanism behind GDM. We assessed the risk for GDM in second pregnancy by change in Body Mass Index (BMI) from first to second pregnancy and whether BMI and gestational weight gain modified the risk.Methods and findingsIn this observational cohort, we included 24,198 mothers and their 2 first pregnancies in data from the Medical Birth Registry of Norway (2006-2014). Weight change, defined as prepregnant BMI in second pregnancy minus prepregnant BMI in first pregnancy, was divided into 6 categories by units BMI (kilo/square meter). Relative risk (RR) estimates were obtained by general linear models for the binary family and adjusted for maternal age at second delivery, country of birth, education, smoking in pregnancy, interpregnancy interval, and year of second birth. Analyses were stratified by BMI (first pregnancy) and gestational weight gain (second pregnancy). Compared to women with stable BMI (-1 to 1), women who gained weight between pregnancies had higher risk of GDM-gaining 1 to 2 units: adjusted RR 2.0 (95% CI 1.5 to 2.7), 2 to 4 units: RR 2.6 (2.0 to 3.5), and ≥4 units: RR 5.4 (4.0 to 7.4). Risk increased significantly both for women with BMI below and above 25 at first pregnancy, although it increased more for the former group. A limitation in our study was the limited data on BMI in 2 pregnancies.ConclusionsThe risk of GDM increased with increasing weight gain from first to second pregnancy, and more strongly among women with BMI < 25 in first pregnancy. Our results suggest weight change as a metabolic mechanism behind the increased risk of GDM, thus weight change should be acknowledged as an independent factor for screening GDM in clinical guidelines. Promoting healthy weight from preconception through the postpartum period should be a target.

Dataset Information

Risk of recurrent corneal erosion in patients with diabetes mellitus in Taiwan: a population-based cohort study.

Objective

Design, setting and participants

Main outcomes and measures

Results

Conclusions

Publications

Risk of recurrent corneal erosion in patients with diabetes mellitus in Taiwan: a population-based cohort study.

Similar Datasets

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