Ontology highlight
ABSTRACT:
SUBMITTER: Zhou S
PROVIDER: S-EPMC7311425 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Zhou Shuo S Zhou Ziyuan Z Ding Kai K Yuan Yaxia Y Loftin Charles C Zheng Fang F Zhan Chang-Guo CG
Scientific reports 20200623 1
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is known as an ideal target for next generation of anti-inflammatory drugs without the side effects of currently available anti-inflammatory drugs. However, there has been no clinically promising mPGES-1 inhibitor identified through traditional drug discovery and development route. Here we report a new approach, called DREAM-in-CDM (Drug Repurposing Effort Applying Integrated Modeling-in vitro/vivo-Clinical Data Mining), to identify an FDA-approve ...[more]