Cyclophilin D: An Integrator of Mitochondrial Function.
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ABSTRACT:
SUBMITTER: Amanakis G
PROVIDER: S-EPMC7311779 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Cyclophilin D: An Integrator of Mitochondrial Function.
Amanakis Georgios G Murphy Elizabeth E
Frontiers in physiology 20200617
Cyclophilin D (CypD) is a mitochondrial peptidyl-prolyl cis-trans isomerase, well-known for regulating the mitochondrial permeability transition pore (PTP), a nonspecific large conductance pore whose opening leads to cell death and has been implicated in ischemia/reperfusion injury in multiple organs, in neurodegenerative disorders, and in muscular dystrophies. While the main target of CypD is a matter of ongoing research, inhibiting CypD protects in models of those diseases making it an interes ...[more]
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