Ontology highlight
ABSTRACT:
SUBMITTER: Ren W
PROVIDER: S-EPMC7311893 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Ren Wenlin W Sun Hunter H Gao George F GF Chen Jianxin J Sun Sean S Zhao Rongqing R Gao Guang G Hu Yalin Y Zhao Gan G Chen Yuxin Y Jin Xia X Fang Feng F Chen Jinggong J Wang Qi Q Gong Sitao S Gao Wen W Sun Yufei Y Su Junchi J He Ailiang A Cheng Xin X Li Min M Xia Chenxi C Li Maohua M Sun Le L
Vaccine 20200624 35
The COVID-19 outbreak has become a global pandemic responsible for over 2,000,000 confirmed cases and over 126,000 deaths worldwide. In this study, we examined the immunogenicity of CHO-expressed recombinant SARS-CoV-2 S1-Fc fusion protein in mice, rabbits, and monkeys as a potential candidate for a COVID-19 vaccine. We demonstrate that the S1-Fc fusion protein is extremely immunogenic, as evidenced by strong antibody titers observed by day 7. Strong virus neutralizing activity was observed on d ...[more]