Ontology highlight
ABSTRACT:
SUBMITTER: Pavan P
PROVIDER: S-EPMC7312402 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Pavan Piero P Monti Elena E Bondí Michela M Fan Chenglei C Stecco Carla C Narici Marco M Reggiani Carlo C Marcucci Lorenzo L
International journal of molecular sciences 20200602 11
Aging of human skeletal muscles is associated with increased passive stiffness, but it is still debated whether muscle fibers or extracellular matrix (ECM) are the determinants of such change. To answer this question, we compared the passive stress generated by elongation of fibers alone and arranged in small bundles in young healthy (Y: 21 years) and elderly (E: 67 years) subjects. The physiological range of sarcomere length (SL) 2.5-3.3 μm was explored. The area of ECM between muscle fibers wa ...[more]