Ontology highlight
ABSTRACT:
SUBMITTER: Rosenkrans ZT
PROVIDER: S-EPMC7312409 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Rosenkrans Zachary T ZT Sun Tuanwei T Jiang Dawei D Chen Weiyu W Barnhart Todd E TE Zhang Ziyi Z Ferreira Carolina A CA Wang Xudong X Engle Jonathan W JW Huang Peng P Cai Weibo W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20200429 12
The manifestation of acute kidney injury (AKI) is associated with poor patient outcomes, with treatment options limited to hydration or renal replacement therapies. The onset of AKI is often associated with a surfeit of reactive oxygen species. Here, it is shown that selenium-doped carbon quantum dots (SeCQDs) have broad-spectrum antioxidant properties and prominent renal accumulation in both healthy and AKI mice. Due to these properties, SeCQDs treat or prevent two clinically relevant cases of ...[more]