Ontology highlight
ABSTRACT:
SUBMITTER: Martellucci S
PROVIDER: S-EPMC7312503 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Martellucci Stefano S Santacroce Costantino C Santilli Francesca F Manganelli Valeria V Sorice Maurizio M Mattei Vincenzo V
International journal of molecular sciences 20200611 11
The prion protein (PrP) is an enigmatic molecule with a pleiotropic effect on different cell types; it is localized stably in lipid raft microdomains and it is able to recruit downstream signal transduction pathways by its interaction with various biochemical partners. Since its discovery, this lipid raft component has been involved in several functions, although most of the publications focused on the pathological role of the protein. Recent studies report a key role of cellular prion protein ( ...[more]