Unknown

Dataset Information

0

Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma.

ABSTRACT: Ependymomas exist within distinct genetic subgroups, but the molecular diversity within individual ependymomas is unknown. We perform multiplatform molecular profiling of 6 spatially distinct samples from an ependymoma with C11orf95-RELA fusion. DNA methylation and RNA sequencing distinguish clusters of samples according to neuronal development gene expression programs that could also be delineated by differences in magnetic resonance blood perfusion. Exome sequencing and phylogenetic analysis reveal epigenomic intratumor heterogeneity and suggest that chromosomal structural alterations may precede accumulation of single-nucleotide variants during ependymoma tumorigenesis. In sum, these findings shed light on the oncogenesis and intratumor heterogeneity of ependymoma.

SUBMITTER: Liu SJ 

PROVIDER: S-EPMC7313374 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Ependymomas exist within distinct genetic subgroups, but the molecular diversity within individual ependymomas is unknown. We perform multiplatform molecular profiling of 6 spatially distinct samples from an ependymoma with C11orf95-RELA fusion. DNA methylation and RNA sequencing distinguish clusters of samples according to neuronal development gene expression programs that could also be delineated by differences in magnetic resonance blood perfusion. Exome sequencing and phylogenetic analysis r  ...[more]

Similar Datasets

Methylation profiling Multiplatform molecular profiling reveals epigenomic intratumor heterogeneity in ependymoma, DNA Methylation
2019-12-20 | GSE142320 | GEO
Genomics Multiplatform molecular profiling reveals epigenomic intratumor heterogeneity in ependymoma, DNA Methylation
| PRJNA596639 | ENA
Unknown Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma.
| S-EPMC7511976 | biostudies-literature
Unknown Histologically resolved multiomics enables precise molecular profiling of human intratumor heterogeneity.
| S-EPMC9282480 | biostudies-literature
Unknown Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity.
| S-EPMC5052795 | biostudies-literature
Unknown Integrative multiplatform-based molecular profiling of human colorectal cancer reveals proteogenomic alterations underlying mitochondrial inactivation.
| S-EPMC8263689 | biostudies-literature
Unknown Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity.
| S-EPMC6214962 | biostudies-literature
Unknown Single-cell epigenomic variability reveals functional cancer heterogeneity.
| S-EPMC5259890 | biostudies-literature
Unknown Intratumor heterogeneity of prognostic DNA-based molecular markers in adrenocortical carcinoma.
| S-EPMC7424337 | biostudies-literature
Unknown Protocol for profiling in vitro intratumor heterogeneity using spatially annotated single-cell sequencing.
| S-EPMC10384656 | biostudies-literature