Dataset Information

Clinical Utility of Buccal Swabs for Sars-Cov-2 Detection in Covid-19-Infected Children.

ABSTRACT: SARS-CoV-2 was detected from at least 1 buccal specimen in 9 out of 11 COVID-19-infected children (81.8%). The viral loads in buccal specimens were substantially lower than those in nasopharyngeal specimens. Buccal swabs for SARS-CoV-2 are not good as screening specimens for COVID-19 in children.

SUBMITTER: Kam KQ

PROVIDER: S-EPMC7313923 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Clinical Utility of Buccal Swabs for Severe Acute Respiratory Syndrome Coronavirus 2 Detection in Coronavirus Disease 2019-Infected Children.

Kam Kai-Qian KQ Yung Chee Fu CF Maiwald Matthias M Chong Chia Yin CY Soong Han Yang HY Loo Liat Hui LH Tan Natalie Woon Hui NWH Li Jiahui J Nadua Karen Donceras KD Thoon Koh Cheng KC

Journal of the Pediatric Infectious Diseases Society 20200701 3

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was detected from at least 1 buccal specimen in 9 of 11 coronavirus disease 2019 (COVID-19)-infected children (81.8%). Viral loads in buccal specimens were substantially lower than those in nasopharyngeal specimens. Buccal swabs are not good as COVID-19 screening specimens in children. ...[more]

PMID: 32463086

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Project description:BackgroundThe Delta (B.1.617.2) SARS-CoV-2 variant was the predominant UK circulating strain between May and November 2021. We investigated whether COVID-19 from Delta infection differed from infection with previous variants in children.MethodsThrough the prospective COVID Symptom Study, 109,626 UK school-aged children were proxy-reported between 28 December 2020 and 8 July 2021. We selected all symptomatic children who tested positive for SARS-CoV-2 and were proxy-reported at least weekly, within two timeframes: 28 December 2020 to 6 May 2021 (Alpha (B.1.1.7), the main UK circulating variant) and 26 May to 8 July 2021 (Delta, the main UK circulating variant), with all children unvaccinated (as per national policy at the time). We assessed illness profiles (symptom prevalence, duration, and burden), hospital presentation, and presence of long (≥28 day) illness, and calculated odds ratios for symptoms presenting within the first 28 days of illness.Results694 (276 younger (5-11 years), 418 older (12-17 years)) symptomatic children tested positive for SARS-CoV-2 with Alpha infection and 706 (227 younger and 479 older) children with Delta infection. Median illness duration was short with either variant (overall cohort: 5 days (IQR 2-9.75) with Alpha, 5 days (IQR 2-9) with Delta). The seven most prevalent symptoms were common to both variants. Symptom burden over the first 28 days was slightly greater with Delta compared with Alpha infection (in younger children, 3 (IQR 2-5) symptoms with Alpha, 4 (IQR 2-7) with Delta; in older children, 5 (IQR 3-8) symptoms with Alpha, 6 (IQR 3-9) with Delta infection ). The odds of presenting several symptoms were higher with Delta than Alpha infection, including headache and fever. Few children presented to hospital, and long illness duration was uncommon, with either variant.ConclusionsCOVID-19 in UK school-aged children due to SARS-CoV-2 Delta strain B.1.617.2 resembles illness due to the Alpha variant B.1.1.7., with short duration and similar symptom burden.

Dataset Information

Clinical Utility of Buccal Swabs for Sars-Cov-2 Detection in Covid-19-Infected Children.

Publications

Clinical Utility of Buccal Swabs for Severe Acute Respiratory Syndrome Coronavirus 2 Detection in Coronavirus Disease 2019-Infected Children.

Similar Datasets

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