High-resolution structures of transient receptor potential vanilloid channels: Unveiling a functionally diverse group of ion channels.
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ABSTRACT:
SUBMITTER: van Goor MK
PROVIDER: S-EPMC7314393 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
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High-resolution structures of transient receptor potential vanilloid channels: Unveiling a functionally diverse group of ion channels.
van Goor Mark K MK de Jager Leanne L Cheng Yifan Y van der Wijst Jenny J
Protein science : a publication of the Protein Society 20200411 7
Transient receptor potential vanilloid (TRPV) channels are part of the superfamily of TRP ion channels and play important roles in widespread physiological processes including both neuronal and non-neuronal pathways. Various diseases such as skeletal abnormalities, chronic pain, and cancer are associated with dysfunction of a TRPV channel. In order to obtain full understanding of disease pathogenesis and create opportunities for therapeutic intervention, it is essential to unravel how these chan ...[more]
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