Ontology highlight
ABSTRACT:
SUBMITTER: Savell KE
PROVIDER: S-EPMC7314536 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Science advances 20200624 26
Drugs of abuse elevate dopamine levels in the nucleus accumbens (NAc) and alter transcriptional programs believed to promote long-lasting synaptic and behavioral adaptations. Here, we leveraged single-nucleus RNA-sequencing to generate a comprehensive molecular atlas of cell subtypes in the NAc, defining both sex-specific and cell type-specific responses to acute cocaine experience in a rat model system. Using this transcriptional map, we identified an immediate early gene expression program tha ...[more]