The relationship between sclerostin and carotid artery atherosclerosis in patients with stage 3-5 chronic kidney disease.

ABSTRACT:

Purpose

Sclerostin is an antagonist of the Wnt/β-catenin pathway. We previously reported that sclerostin is closely related to carotid artery atherosclerosis and long-term outcome in hemodialysis patients. The present study investigated the association between sclerostin, renal function, and carotid artery atherosclerosis in non-dialysis patients with stage 3-5 chronic kidney disease (CKD 3-5ND).

Methods

A total of 140 patients with CKD 3-5ND were enrolled in this cross-sectional study. The Chronic Kidney Disease Epidemiology Collaboration equation was used to calculate estimated glomerular filtration rate (eGFR). Atherosclerotic plaques in the carotid artery were detected by B-mode Doppler ultrasound. Blood samples were collected to assess serum sclerostin levels. Unconditi

SUBMITTER: Zhao B 

PROVIDER: S-EPMC7314717 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature