Durable protection against repeated penile exposures to simian-human immunodeficiency virus by broadly neutralizing antibodies.

ABSTRACT: Penile acquisition of HIV accounts for most infections among men globally. Nevertheless, candidate HIV interventions for men advance to clinical trials without preclinical efficacy data, due primarily to a paucity of relevant animal models of penile HIV infection. Using our recently developed macaque model, we show that a single subcutaneous administration of broadly neutralizing antibody (bNAb) 10-1074 conferred durable protection against repeated penile exposures to simian-human immunodeficiency virus (SHIV_SF162P3). Macaques co-administered bNAbs 10-1074 and 3BNC117, or 3BNC117 alone, also exhibited significant protection against repeated vaginal SHIV_AD8-EO exposures. Regression modeling estimated that individual plasma bNAb concentrations of 5 μg ml^-1 co

SUBMITTER: Garber DA 

PROVIDER: S-EPMC7314794 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature