Ontology highlight
ABSTRACT:
SUBMITTER: Santos JC
PROVIDER: S-EPMC7314798 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Santos José Carlos JC Boucher Dave D Schneider Larisa Kapinos LK Demarco Benjamin B Dilucca Marisa M Shkarina Kateryna K Heilig Rosalie R Chen Kaiwen W KW Lim Roderick Y H RYH Broz Petr P
Nature communications 20200624 1
The human non-canonical inflammasome controls caspase-4 activation and gasdermin-D-dependent pyroptosis in response to cytosolic bacterial lipopolysaccharide (LPS). Since LPS binds and oligomerizes caspase-4, the pathway is thought to proceed without dedicated LPS sensors or an activation platform. Here we report that interferon-induced guanylate-binding proteins (GBPs) are required for non-canonical inflammasome activation by cytosolic Salmonella or upon cytosolic delivery of LPS. GBP1 associat ...[more]