Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer.
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ABSTRACT:
SUBMITTER: Lin Y
PROVIDER: S-EPMC7314803 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer.
Lin Yingsong Y Nakatochi Masahiro M Hosono Yasuyuki Y Ito Hidemi H Kamatani Yoichiro Y Inoko Akihito A Sakamoto Hiromi H Kinoshita Fumie F Kobayashi Yumiko Y Ishii Hiroshi H Ozaka Masato M Sasaki Takashi T Matsuyama Masato M Sasahira Naoki N Morimoto Manabu M Kobayashi Satoshi S Fukushima Taito T Ueno Makoto M Ohkawa Shinichi S Egawa Naoto N Kuruma Sawako S Mori Mitsuru M Nakao Haruhisa H Adachi Yasushi Y Okuda Masumi M Osaki Takako T Kamiya Shigeru S Wang Chaochen C Hara Kazuo K Shimizu Yasuhiro Y Miyamoto Tatsuo T Hayashi Yuko Y Ebi Hiromichi H Kohmoto Tomohiro T Imoto Issei I Kasugai Yumiko Y Murakami Yoshinori Y Akiyama Masato M Ishigaki Kazuyoshi K Matsuda Koichi K Hirata Makoto M Shimada Kazuaki K Okusaka Takuji T Kawaguchi Takahisa T Takahashi Meiko M Watanabe Yoshiyuki Y Kuriki Kiyonori K Kadota Aya A Okada Rieko R Mikami Haruo H Takezaki Toshiro T Suzuki Sadao S Yamaji Taiki T Iwasaki Motoki M Sawada Norie N Goto Atsushi A Kinoshita Kengo K Fuse Nobuo N Katsuoka Fumiki F Shimizu Atsushi A Nishizuka Satoshi S SS Tanno Kozo K Suzuki Ken K Okada Yukinori Y Horikoshi Momoko M Yamauchi Toshimasa T Kadowaki Takashi T Yu Herbert H Zhong Jun J Amundadottir Laufey T LT Doki Yuichiro Y Ishii Hideshi H Eguchi Hidetoshi H Bogumil David D Haiman Christopher A CA Le Marchand Loic L Mori Masaki M Risch Harvey H Setiawan Veronica W VW Tsugane Shoichiro S Wakai Kenji K Yoshida Teruhiko T Matsuda Fumihiko F Kubo Michiaki M Kikuchi Shogo S Matsuo Keitaro K
Nature communications 20200624 1
Pancreatic cancer is the fourth leading cause of cancer-related deaths in Japan. To identify risk loci, we perform a meta-analysis of three genome-wide association studies comprising 2,039 pancreatic cancer patients and 32,592 controls in the Japanese population. Here, we identify 3 (13q12.2, 13q22.1, and 16p12.3) genome-wide significant loci (P < 5.0 × 10<sup>-8</sup>), of which 16p12.3 has not been reported in the Western population. The lead single nucleotide polymorphism (SNP) at 16p12.3 is ...[more]
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