Risk Factors for Cardiovascular Events in Patients on Antidementia Medications.
Ontology highlight
ABSTRACT: Objective
To identify characteristics associated with an increased risk of cardiovascular events in patients diagnosed with Alzheimer disease (AD) and treated with antidementia medications.Methods
Demographics, diagnoses, and medication usage of 30 433 Medicare patients were analyzed using 2006 to 2013 claims data and a combined model of screening, ranking and stepwise logistic regressions to evaluate factors associated with composite outcomes of 6 cardiovascular events.Results
Incidence rate of at least 1 cardiovascular event was 25.1%. Fifty-five factors were identified from the 10 381 candidate variables by the combined model with a c-statistic of 67% and an accuracy of 75%. Factors associated with increased risk of cardiovascular events include history of heart rhythm disorders, alteration of consciousness (odds ratio [OR]: 1.25; 95% confidence interval [CI]: 1.14-1.36), and usage of ?-blockers (OR: 1.19; 95% CI: 1.13-1.27).Conclusions
Clinicians should consider the increased risk of cardiovascular events in patients with AD with heart rhythm disorders and on ?-blockers.
SUBMITTER: He M
PROVIDER: S-EPMC7315406 | biostudies-literature | 2020 Jan-Dec
REPOSITORIES: biostudies-literature
Publications
Risk Factors for Cardiovascular Events in Patients on Antidementia Medications.
He Meiqi M Stevenson James M JM Zhang Yuting Y Hernandez Inmaculada I
American journal of Alzheimer's disease and other dementias 20200101
<h4>Objective</h4>To identify characteristics associated with an increased risk of cardiovascular events in patients diagnosed with Alzheimer disease (AD) and treated with antidementia medications.<h4>Methods</h4>Demographics, diagnoses, and medication usage of 30 433 Medicare patients were analyzed using 2006 to 2013 claims data and a combined model of screening, ranking and stepwise logistic regressions to evaluate factors associated with composite outcomes of 6 cardiovascular events.<h4>Resul ...[more]
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