Ontology highlight
ABSTRACT:
SUBMITTER: Beilina A
PROVIDER: S-EPMC7315779 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Beilina Alexandra A Bonet-Ponce Luis L Kumaran Ravindran R Kordich Jennifer J JJ Ishida Morié M Mamais Adamantios A Kaganovich Alice A Saez-Atienzar Sara S Gershlick David C DC Roosen Dorien A DA Pellegrini Laura L Malkov Vlad V Fell Matthew J MJ Harvey Kirsten K Bonifacino Juan S JS Moore Darren J DJ Cookson Mark R MR
Cell reports 20200501 5
Mutations in Leucine-rich repeat kinase 2 (LRRK2) cause Parkinson's disease (PD). However, the precise function of LRRK2 remains unclear. We report an interaction between LRRK2 and VPS52, a subunit of the Golgi-associated retrograde protein (GARP) complex that identifies a function of LRRK2 in regulating membrane fusion at the trans-Golgi network (TGN). At the TGN, LRRK2 further interacts with the Golgi SNAREs VAMP4 and Syntaxin-6 and acts as a scaffolding platform that stabilizes the GARP-SNARE ...[more]