Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment.
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ABSTRACT: While remdesivir has garnered much hope for its moderate anti-Covid-19 effects, its parent nucleoside, GS-441524, has been overlooked. Pharmacokinetic analysis of remdesivir evidences premature serum hydrolysis to GS-441524; GS-441524 is the predominant metabolite reaching the lungs. With its synthetic simplicity and in vivo efficacy in the veterinary setting, we contend that GS-441524 is superior to remdesivir for Covid-19 treatment.
SUBMITTER: Yan VC
PROVIDER: S-EPMC7315846 | biostudies-literature |
REPOSITORIES: biostudies-literature
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