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Attenuated Novel SARS Coronavirus 2 Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient on Ruxolitinib.

ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) has a high death rate in patients with comorbidities or in an immunocompromised state. We report a mild and attenuated SARS CoV-2 infection in a patient who is 17 months post stem cell transplantation and maintained on the JAK/STAT inhibitor ruxolitinib, a proposed novel therapy for SARS CoV-2 pneumonia.

SUBMITTER: Foss FM

PROVIDER: S-EPMC7316063 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Attenuated Novel SARS Coronavirus 2 Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient on Ruxolitinib.

Foss Francine M FM Rubinowitz Ami A Landry Marie L ML Isufi Iris I Gowda Lohith L Seropian Stuart S Perreault Sarah S Shenoi Sheela V SV

Clinical lymphoma, myeloma & leukemia 20200625 11

Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) has a high death rate in patients with comorbidities or in an immunocompromised state. We report a mild and attenuated SARS CoV-2 infection in a patient who is 17 months post stem cell transplantation and maintained on the JAK/STAT inhibitor ruxolitinib, a proposed novel therapy for SARS CoV-2 pneumonia. ...[more]

PMID: 32727701

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