Ontology highlight
ABSTRACT:
SUBMITTER: Shi Z
PROVIDER: S-EPMC7316512 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Shi Zhigang Z Pelletier Nicole E NE Wong Jennifer J Li Baoxin B Sdrulla Andrei D AD Madden Christopher J CJ Marks Daniel L DL Brooks Virginia L VL
eLife 20200615
Whether leptin acts in the paraventricular nucleus (PVN) to increase sympathetic nerve activity (SNA) is unclear, since PVN leptin receptors (LepR) are sparse. We show in rats that PVN leptin slowly increases SNA to muscle and brown adipose tissue, because it induces the expression of its own receptor and synergizes with local glutamatergic neurons. PVN LepR are not expressed in astroglia and rarely in microglia; instead, glutamatergic neurons express LepR, some of which project to a key presymp ...[more]