Dataset Information

Normal Reference Values for Left Atrial Strain and Its Determinants from a Large Korean Multicenter Registry.

ABSTRACT:

Background

Left atrial (LA) strain is a novel parameter of LA function. However, its reference value has not been established, and the determining factors for LA strain remain elusive. We aimed to present LA strain with reservoir, conduit, and contractile components and associated parameters in a large-sized group of healthy individuals.

Methods

The present study was from a prospective multicenter registry in South Korea. Subjects who had no history of cardiovascular disease with adequate images were eligible for inclusion. LA reservoir, conduit, and contractile strains (LAS_RES, LAS_CD and LAS_CT, respectively) were measured. Left ventricular global longitudinal strain (LV GLS) and early and late diastolic strain rates (DSR_e and DSR_a, respectively) were also evaluated.

Results

Among a total of 324 subjects (mean age: 49 ± 16 years, 167 females), the mean LAS_RES, LAS_CD, and LAS_CT values were 35.9% ± 10.6%, 21.9% ± 9.3%, and 13.9% ± 3.6%, respectively. Mean LV GLS was -20.4% ± 2.2%, and mean DSR_e and DSR_a were 1.6 ± 0.4 s^-1 and 0.8 ± 0.3 s^-1, respectively. With aging, LAS_RES and LAS_CD showed significant decreases. Factors showing independent associations with LAS_RES were age (B = -0.425, p < 0.001), DSR_e (B = 4.706, p = 0.001), and LV GLS (B = -1.081, p < 0.001). Age (B = -0.319, p < 0.001), DSR_e (B = 4.140, p = 0.002), DSR_a (B = -3.409, p = 0.018), and LV GLS (B = -0.783, p < 0.001) showed associations with LAS_CD. With LAS_CT, only DSR_a showed a correlation (R = 0.277, p < 0.001).

Conclusions

We presented LA strain in a large-sized group of healthy subjects. Age is a significant determinant of LA function. Associations of LA strain with diastolic strain rates and LV GLS reflect cardiac mechanics.

SUBMITTER: Sun BJ

PROVIDER: S-EPMC7316554 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Publications

Normal Reference Values for Left Atrial Strain and Its Determinants from a Large Korean Multicenter Registry.

Sun Byung Joo BJ Park Jae Hyeong JH Lee Minyeong M Choi Jin Oh JO Lee Ju Hee JH Shin Mi Seung MS Kim Mi Jeong MJ Jung Hae Ok HO Park Jeong Rang JR Sohn Il Suk IS Kim Hyungseop H Kim Hyung Kwan HK Cho Goo Yeong GY Park Jin Sun JS Shim Chi Young CY Shin Sung Hee SH Kim Kye Hun KH Kim Woo Shik WS Park Seung Woo SW

Journal of cardiovascular imaging 20200701 3

<h4>Background</h4>Left atrial (LA) strain is a novel parameter of LA function. However, its reference value has not been established, and the determining factors for LA strain remain elusive. We aimed to present LA strain with reservoir, conduit, and contractile components and associated parameters in a large-sized group of healthy individuals.<h4>Methods</h4>The present study was from a prospective multicenter registry in South Korea. Subjects who had no history of cardiovascular disease with ...[more]

PMID: 32583635

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Project description:BackgroundLeft atrial appendage occlusion (LAAO) to prevent stroke in patients with atrial fibrillation has been evaluated in 2 randomized trials; post-approval clinical data are limited.ObjectivesThe purpose of this study was to describe the National Cardiovascular Data Registry (NCDR) LAAO Registry and present patient, hospital, and physician characteristics and in-hospital adverse event rates for Watchman procedures in the United States during its first 3 years.MethodsThe authors describe the LAAO Registry structure and governance, the outcome adjudication processes, and the data quality and collection processes. They characterize the patient population, performing hospitals, and in-hospital adverse event rates.ResultsA total of 38,158 procedures from 495 hospitals performed by 1,318 physicians in the United States were included between January 2016 and December 2018. The mean patient age was 76.1 ± 8.1 years, the mean CHA2DS2-VASc (congestive heart failure, hypertension, 65 years of age and older, diabetes mellitus, previous stroke or transient ischemic attack, vascular disease, 65 to 74 years of age, female) score was 4.6 ± 1.5, and the mean HAS-BLED (hypertension, abnormal renal/liver function, stroke, bleeding history or predisposition, labile international normalized ratio, elderly, drugs/alcohol concomitantly) score was 3.0 ± 1.1. The median annual number of LAAO procedures performed for hospitals was 30 (interquartile range: 18 to 44) and for physicians was 12 (interquartile range: 8 to 20). Procedures were canceled or aborted in 7% of cases; among cases in which a device was deployed, 98.1% were implanted with <5-mm leak. Major in-hospital adverse events occurred in 2.16% of patients; the most common complications were pericardial effusion requiring intervention (1.39%) and major bleeding (1.25%), whereas stroke (0.17%) and death (0.19%) were rare.ConclusionsThe LAAO Registry has enrolled >38,000 patients implanted with the device. Patients were generally older with more comorbidities than those enrolled in the pivotal trials; however, major in-hospital adverse event rates were lower than reported in those trials.

Dataset Information

Normal Reference Values for Left Atrial Strain and Its Determinants from a Large Korean Multicenter Registry.

Background

Methods

Results

Conclusions

Publications

Normal Reference Values for Left Atrial Strain and Its Determinants from a Large Korean Multicenter Registry.

Similar Datasets

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