Ontology highlight
ABSTRACT:
SUBMITTER: Gao X
PROVIDER: S-EPMC7316719 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Gao Xiang X Dong Xiaoqun X Li Xuanxuan X Liu Zhijie Z Liu Haiguang H
Scientific reports 20200625 1
Disulfide bonds are covalently bonded sulfur atoms from cysteine pairs in protein structures. Due to the importance of disulfide bonds in protein folding and structural stability, artificial disulfide bonds are often engineered by cysteine mutation to enhance protein structural stability. To facilitate the experimental design, we implemented a method based on neural networks to predict amino acid pairs for cysteine mutations to form engineered disulfide bonds. The designed neural network was tra ...[more]