Ontology highlight
ABSTRACT:
SUBMITTER: Tsepilov YA
PROVIDER: S-EPMC7316754 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Tsepilov Yakov A YA Freidin Maxim B MB Shadrina Alexandra S AS Sharapov Sodbo Z SZ Elgaeva Elizaveta E EE Zundert Jan van JV Karssen Lennart С LС Suri Pradeep P Williams Frances M K FMK Aulchenko Yurii S YS
Communications biology 20200625 1
Chronic musculoskeletal pain affects all aspects of human life. However, mechanisms of its genetic control remain poorly understood. Genetic studies of pain are complicated by the high complexity and heterogeneity of pain phenotypes. Here, we apply principal component analysis to reduce phenotype heterogeneity of chronic musculoskeletal pain at four locations: the back, neck/shoulder, hip, and knee. Using matrices of genetic covariances, we constructed four genetically independent phenotypes (GI ...[more]