Association between uric acid levels and cardio-renal outcomes and death in patients with type 2 diabetes: A subanalysis of EMPA-REG OUTCOME.

ABSTRACT: In the EMPA-REG OUTCOME trial, we explored the association between pre-randomization uric acid level tertile (<309.30??mol/L; 309.30 to <387.21??mol/L; ?387.21??mol/L) and cardiovascular (CV) death, hospitalization for heart failure (HHF), HHF or CV death, all-cause mortality, three-point major adverse CV events (MACE), and incident or worsening nephropathy. Patients with type 2 diabetes and CV disease received empagliflozin or placebo. The median baseline plasma uric acid level was 344.98??mol/L, and patients' baseline characteristics were mainly balanced across tertiles. Baseline uric acid levels were associated with cardio-renal outcomes: in the placebo group, for the highest versus lowest tertile, the multivariable hazard ratios for three-point MACE, HHF or CV death, and incident or worsening nephropathy were 1.22 (95% confidence interval [CI] 0.89-1.67; P = 0.2088), 1.51 (95% CI 1.02-2.23; P = 0.0396) and 1.77 (95% CI 1.33-2.34; P?0.05. Further investigation of these relationships is required.

SUBMITTER: Verma S 

PROVIDER: S-EPMC7317186 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature