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Protein Delivery of Cell-Penetrating Zinc-Finger Activators Stimulates Latent HIV-1-Infected Cells.

ABSTRACT: Eradication of HIV-1 infection is impeded by the persistence of cellular reservoirs harboring latent provirus. Stimulation of latent viral expression is considered critical to target HIV reservoirs for elimination. Perdigão et al. established a “gene-free” approach to specifically activate latent HIV expression through protein delivery of cell-penetrating zinc-finger activators. Engineered zinc-finger activators can translocate across the cell membrane and target the HIV promoter to induce viral expression from latently infected cells, providing a novel and safe route for the elimination of HIV-1 reservoirs.

SUBMITTER: Perdigao PRL

PROVIDER: S-EPMC7317221 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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