Ontology highlight
ABSTRACT:
SUBMITTER: Horgan C
PROVIDER: S-EPMC7317226 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Horgan Claire C Kartsios Charalampos C Nikolousis Emmanouil E Shankara Paneesha P Kishore Bhuvan B Lovell Richard R Murthy Vidhya V Rudzki Zbigniew Z Dyer Sara S Holtom Pam P Thompson Gillian G Kaparou Maria M Xenou Evgenia E Lloyd Rebecca R Venkatadasari Indrani I Kanellopoulos Alexandros Georgios AG
Leukemia research reports 20200618
Herein we present a female patient aged 61 with Philadelphia negative acute lymphoblastic leukaemia demonstrating near haploid karyotype and abnormal TP53 expression at diagnosis, who relapsed with lineage switch as Acute Monocytic Leukemia post allogeneic stem cell transplantation. Molecular analysis established that both neoplasms were derived from the same founder clone. The leukemic lineage switch phenomenon has recently re-attracted interest as mechanism of leukemic evasion post treatment w ...[more]