Biofilm-inspired adhesive and antibacterial hydrogel with tough tissue integration performance for sealing hemostasis and wound healing.

ABSTRACT: Highlights•We put forward a novel method inspired form staphylococcal biofilm for fabricating hydrogel hemostasis material. To the best of our knowledge, this is the first report of designing staphylococcal biofilm inspired adhesive hydrogel for in vivo sealing hemostasis.•Unlike the traditional acrylamide (AM) based hydrogels, the as-prepared DBAH were purified before further measurements and application by repetitive cycles of deionized water and ethyl alcohol to prevent the potential cytotoxicity of unreacted NMA monomers.•The as-prepared DBAH can intimately integrate with biological tissue and exhibit superior capacity of in vivo hemostatic by sealing the bleeding wound even in wet and dynamic rabbit's heart.

SUBMITTER: Han W 

PROVIDER: S-EPMC7317234 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature