Ontology highlight
ABSTRACT:
SUBMITTER: Hemmerich J
PROVIDER: S-EPMC7317375 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Hemmerich Jennifer J Troger Florentina F Füzi Barbara B F Ecker Gerhard G
Molecular informatics 20200323 5
Over the last few years more and more organ and idiosyncratic toxicities were linked to mitochondrial toxicity. Despite well-established assays, such as the seahorse and Glucose/Galactose assay, an in silico approach to mitochondrial toxicity is still feasible, particularly when it comes to the assessment of large compound libraries. Therefore, in silico approaches could be very beneficial to indicate hazards early in the drug development pipeline. By combining multiple endpoints, we derived the ...[more]