Ontology highlight
ABSTRACT:
SUBMITTER: Grujic M
PROVIDER: S-EPMC7317424 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Grujic Mirjana M Hellman Lars L Gustafson Ann-Marie AM Akula Srinivas S Melo Fabio Rabelo FR Pejler Gunnar G
Pigment cell & melanoma research 20200119 4
Tryptase-positive mast cells populate melanomas, but it is not known whether tryptase impacts on melanoma progression. Here we addressed this and show that melanoma growth is significantly higher in tryptase-deficient (Mcpt6<sup>-/-</sup> ) versus wild-type mice. Histochemical analysis showed that mast cells were frequent in the tumor stroma of both wild-type and Mcpt6<sup>-/-</sup> mice, and also revealed their presence within the tumor parenchyma. Confocal microscopy analysis revealed that try ...[more]