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The "Green" Electrochemical Synthesis of Periodate.

ABSTRACT: High-grade periodate is relatively expensive, but is required for many sensitive applications such as the synthesis of active pharmaceutical ingredients. These high costs originate from using lead dioxide anodes in contemporary electrochemical methods and from expensive starting materials. A direct and cost-efficient electrochemical synthesis of periodate from iodide, which is less costly and relies on a readily available starting material, is reported. The oxidation is conducted at boron-doped diamond anodes, which are durable, metal-free, and nontoxic. The avoidance of lead dioxide ultimately lowers the cost of purification and quality assurance. The electrolytic process was optimized by statistical methods and was scaled up in an electrolysis flow cell that enhanced the space-time yields by a cyclization protocol. An LC-PDA analytical protocol was established enabling simple quantification of iodide, iodate, and periodate simultaneously with remarkable precision.

SUBMITTER: Arndt S

PROVIDER: S-EPMC7317427 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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The "Green" Electrochemical Synthesis of Periodate.

Arndt Sebastian S Weis Dominik D Donsbach Kai K Waldvogel Siegfried R SR

Angewandte Chemie (International ed. in English) 20200415 21

High-grade periodate is relatively expensive, but is required for many sensitive applications such as the synthesis of active pharmaceutical ingredients. These high costs originate from using lead dioxide anodes in contemporary electrochemical methods and from expensive starting materials. A direct and cost-efficient electrochemical synthesis of periodate from iodide, which is less costly and relies on a readily available starting material, is reported. The oxidation is conducted at boron-doped ...[more]

PMID: 32181555

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