Fc-gamma IIIa-V158F receptor polymorphism contributes to the severity of Guillain-Barre syndrome.

ABSTRACT: OBJECTIVE:Guillain-Barré syndrome (GBS) is a rare, life-threatening disorder of the peripheral nervous system. Immunoglobulin G Fc-gamma receptors (Fc?Rs) mediate and regulate diverse effector functions and are involved in the pathogenesis of GBS. We investigated whether the Fc?R polymorphisms Fc?RIIa H/R131 (rs1801274), Fc?RIIIa V/F158 (rs396991), and Fc?RIIIb NA1/NA2, and their haplotype patterns affect the affinity of IgG-Fc?R interactivity and influence GBS susceptibility and severity. METHODS:We determined Fc?R polymorphisms in 303 patients with GBS and 302 ethnically matched healthy individuals from Bangladesh by allele-specific polymerase chain reaction. Pairwise linkage disequilibrium and haplotype patterns were analyzed based on D ?statistics and the genotype package of R statistics, respectively. Logistic regression analysis and Fisher's exact test with corrected P (Pc) values were employed for statistical comparisons. RESULTS:Fc?RIIIa-V158F was associated with the severe form of GBS compared to the mild form (P = 0.005, OR = 2.24, 95% CI = 1.28-3.91; Pc = 0.015); however, Fc?R genotypes and haplotype patterns did not show any association with GBS susceptibility compared to healthy controls. Fc?RIIIa-V/V158 and Fc?RIIIb-NA2/2 were associated with recent Campylobacter jejuni infection (P ? 0.001, OR = 0.36, 95% CI = 0.23-0.56; Pc ? 0.003 and P = 0.004, OR = 1.70, 95% CI = 1.18-2.44; Pc ? 0.012, respectively). Haplotype 1 (Fc?RIIa-H131R- Fc?RIIIa-V158F- Fc?RIIIb-NA1/2) and the Fc?RIIIb-NA2/2 genotype were more prevalent among anti-GM1 antibody-positive patients (P = 0.031, OR = 9.61, 95% CI = 1.24-74.77, Pc = 0.279; P = 0.027, OR = 1.62, 95% CI = 1.06-2.5, Pc = 0.081, respectively). INTERPRETATION:Fc?R polymorphisms and haplotypes are not associated with susceptibility to GBS, though the Fc?RIIIa-V158F genotype is associated with the severity of GBS.

SUBMITTER: Hayat S 

PROVIDER: S-EPMC7317642 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature