Ontology highlight
ABSTRACT:
SUBMITTER: Mulder S
PROVIDER: S-EPMC7317707 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Mulder Skander S Hammarstedt Ann A Nagaraj Sunil B SB Nair Viji V Ju Wenjun W Hedberg Jonatan J Greasley Peter J PJ Eriksson Jan W JW Oscarsson Jan J Heerspink Hiddo J L HJL
Diabetes, obesity & metabolism 20200325 7
<h4>Aim</h4>To investigate which metabolic pathways are targeted by the sodium-glucose co-transporter-2 inhibitor dapagliflozin to explore the molecular processes involved in its renal protective effects.<h4>Methods</h4>An unbiased mass spectrometry plasma metabolomics assay was performed on baseline and follow-up (week 12) samples from the EFFECT II trial in patients with type 2 diabetes with non-alcoholic fatty liver disease receiving dapagliflozin 10 mg/day (n = 19) or placebo (n = 6). Transc ...[more]