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Expression of small RNAs of Bordetella pertussis colonizing murine tracheas.


ABSTRACT: We performed RNA sequencing on Bordetella pertussis, the causative agent of whooping cough, and identified nine novel small RNAs (sRNAs) that were transcribed during the bacterial colonization of murine tracheas. Among them, four sRNAs were more strongly expressed in vivo than in vitro. Moreover, the expression of eight sRNAs was not regulated by the BvgAS two-component system, which is the master regulator for the expression of genes contributing to the bacterial infection. The present results suggest a BvgAS-independent gene regulatory system involving the sRNAs that is active during B. pertussis infection.

SUBMITTER: Hiramatsu Y 

PROVIDER: S-EPMC7317797 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Expression of small RNAs of Bordetella pertussis colonizing murine tracheas.

Hiramatsu Yukihiro Y   Suzuki Koichiro K   Motooka Daisuke D   Nakamura Shota S   Horiguchi Yasuhiko Y  

Microbiology and immunology 20200513 6


We performed RNA sequencing on Bordetella pertussis, the causative agent of whooping cough, and identified nine novel small RNAs (sRNAs) that were transcribed during the bacterial colonization of murine tracheas. Among them, four sRNAs were more strongly expressed in vivo than in vitro. Moreover, the expression of eight sRNAs was not regulated by the BvgAS two-component system, which is the master regulator for the expression of genes contributing to the bacterial infection. The present results  ...[more]

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