Dynamic assessment of venous thromboembolism risk in patients with cancer by longitudinal D-Dimer analysis: A prospective study.

ABSTRACT:

Background

Venous thromboembolism (VTE) is a frequent complication of cancer. Elevated D-dimer is associated with an increased risk of cancer-associated VTE. Whether changes in D-dimer over time harbor additional prognostic information that may be exploited clinically for dynamic prediction of VTE is unclear.

Objectives

To explore the potential role of longitudinal D-dimer trajectories for personalized prediction of cancer-associated VTE.

Patients/methods

A total of 167 patients with active malignancy were prospectively enrolled (gastrointestinal: n = 59 [35%], lung: n = 56 [34%], brain: n = 50 [30%], others: n = 2 [1%]; metastatic disease: n = 74 [44%]). D-dimer (median = 0.8 µg/mL [25th-75th percentile: 0.4-2.0]) was measured at baseline and during 602 monthly follo

SUBMITTER: Posch F 

PROVIDER: S-EPMC7317804 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature