Thioridazine Is an Efflux Pump Inhibitor in Mycobacterium avium Complex but of Limited Clinical Relevance.
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ABSTRACT:
SUBMITTER: Ruth MM
PROVIDER: S-EPMC7318027 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
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Thioridazine Is an Efflux Pump Inhibitor in Mycobacterium avium Complex but of Limited Clinical Relevance.
Ruth Mike Marvin MM Pennings Lian J LJ Koeken Valerie A C M VACM Schildkraut Jodie A JA Hashemi Aria A Wertheim Heiman F L HFL Hoefsloot Wouter W van Ingen Jakko J
Antimicrobial agents and chemotherapy 20200623 7
Treatment of <i>Mycobacterium avium</i> complex pulmonary disease (MAC-PD) is challenging partly due to high efflux pump expression. Thioridazine might block these efflux pumps. We explore the efficacy of thioridazine against <i>M. avium</i> isolates using MICs, time-kill combination assays, <i>ex vivo</i> macrophage infection assays, and efflux assays. Thioridazine is bactericidal against <i>M. avium</i>, inhibits intracellular growth at 2× MIC, and blocks ethidium bromide efflux. However, its ...[more]
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