Ontology highlight
ABSTRACT:
SUBMITTER: Lantz L
PROVIDER: S-EPMC7318160 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Lantz Linda L Shirani Hamid H Klingstedt Therése T Nilsson K Peter R KPR
Chemistry (Weinheim an der Bergstrasse, Germany) 20200515 33
Protein deposits are associated with many devastating diseases and fluorescent ligands able to visualize these pathological entities are essential. Here, we report the synthesis of thiophene-based donor-acceptor-donor heptameric ligands that can be utilized for spectral assignment of distinct amyloid-β (Aβ) aggregates, one of the pathological hallmarks in Alzheimer's disease. The ability of the ligands to selectively distinguish Aβ deposits was abolished when the chemical composition of the liga ...[more]