Dataset Information
Cardiac biomarkers of prognostic importance in chronic obstructive pulmonary disease.
Ontology highlight
ABSTRACT: Background
Ischemic heart disease is common in COPD and associated with worse prognosis. This study aimed to investigate the presence and prognostic impact of biomarkers of myocardial injury and ischemia among individuals with COPD and normal lung function, respectively.Methods
In 2002-04, all individuals with airway obstruction (FEV1/VC?ResultsHs-cTnI concentrations were above the risk stratification threshold of ?5?ng/L in 31.1 and 24.9% of those with COPD and normal lung function, respectively. Ischemic ECG abnormalities were present in 14.8 and 13.4%, while 7.7 and 6.6% had both elevated hs-cTnI concentrations and ischemic ECG abnormalities. The 5-year cumulative mortality was higher in those with COPD than those with normal lung function (13.6% vs. 7.7%, p?ConclusionsIn this study, elevated hs-cTnI concentrations in combination with myocardial ischemia on the electrocardiogram were associated with a more than four-fold increased risk for death in a population-based COPD-cohort, independent of disease severity.
SUBMITTER: Nilsson U
PROVIDER: S-EPMC7318493 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Cardiac biomarkers of prognostic importance in chronic obstructive pulmonary disease.
Respiratory research 20200626 1
<h4>Background</h4>Ischemic heart disease is common in COPD and associated with worse prognosis. This study aimed to investigate the presence and prognostic impact of biomarkers of myocardial injury and ischemia among individuals with COPD and normal lung function, respectively.<h4>Methods</h4>In 2002-04, all individuals with airway obstruction (FEV<sub>1</sub>/VC < 0.70, n = 993) were identified from population-based cohorts, together with age and sex-matched non-obstructive referents. At re-ex ...[more]
