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Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19.


ABSTRACT: Tocilizumab has been proposed as a means of opposing hyperinflammatory responses in intensive care patients with COVID-19. Here, we briefly discuss the potentially multiple, synergistic mechanisms whereby tocilizumab might exert therapeutic activity, mostly focusing on the production of tryptophan-derived catabolites that would result from blockade of IL-6 signaling, as contextualized to the cytokine storm occurring in COVID-19 patients.

SUBMITTER: Belladonna ML 

PROVIDER: S-EPMC7319082 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19.

Belladonna Maria Laura ML   Orabona Ciriana C  

Frontiers in pharmacology 20200619


Tocilizumab has been proposed as a means of opposing hyperinflammatory responses in intensive care patients with COVID-19. Here, we briefly discuss the potentially multiple, synergistic mechanisms whereby tocilizumab might exert therapeutic activity, mostly focusing on the production of tryptophan-derived catabolites that would result from blockade of IL-6 signaling, as contextualized to the cytokine storm occurring in COVID-19 patients. ...[more]

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