Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC7319104 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Liu Ying Y Chen Xi X Choi Yeon Ja YJ Yang Ning N Song Zhongya Z Snedecor Elizabeth R ER Liang Wei W Leung Elaine Lai-Han EL Zhang Lianfeng L Qin Chuan C Chen Jiang J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20200218 4
Embryonic development of the alveolar sac of the lung is dependent upon multiple signaling pathways to coordinate cell growth, migration, and the formation of the extracellular matrix. Here, we identify GORAB as a regulator of embryonic alveolar sac formation as genetically disrupting the Gorab gene in mice resulted in fatal saccular maturation defects characterized by a thickened lung mesenchyme. This abnormality is not associated with impairments in cellular proliferation and death, but aberra ...[more]