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Cell organelle targeting of near-infrared croconaine dye controls photothermal outcome.

ABSTRACT: Near-infrared croconaine-peptide conjugates that target the cell nucleus promote photothermal induced cell death. In contrast, a croconaine-morpholine conjugate that targets the cell lysosomes promotes lysosome permeabilization without measurable cell phototoxicity.

SUBMITTER: Wen Y

PROVIDER: S-EPMC7319869 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Cell organelle targeting of near-infrared croconaine dye controls photothermal outcome.

Wen Ying Y McGarraugh Hannah H HH Schreiber Cynthia L CL Smith Bradley D BD

Chemical communications (Cambridge, England) 20200601 51

Near-infrared croconaine-peptide conjugates that target the cell nucleus promote photothermal induced cell death. In contrast, a croconaine-morpholine conjugate that targets the cell lysosomes promotes lysosome permeabilization without measurable cell phototoxicity. ...[more]

PMID: 32436506

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