Ontology highlight
ABSTRACT:
SUBMITTER: Silva MC
PROVIDER: S-EPMC7320012 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Silva M Catarina MC Nandi Ghata A GA Tentarelli Sharon S Gurrell Ian K IK Jamier Tanguy T Lucente Diane D Dickerson Bradford C BC Brown Dean G DG Brandon Nicholas J NJ Haggarty Stephen J SJ
Nature communications 20200626 1
Tauopathies are neurodegenerative diseases associated with accumulation of abnormal tau protein in the brain. Patient iPSC-derived neuronal cell models replicate disease-relevant phenotypes ex vivo that can be pharmacologically targeted for drug discovery. Here, we explored autophagy as a mechanism to reduce tau burden in human neurons and, from a small-molecule screen, identify the mTOR inhibitors OSI-027, AZD2014 and AZD8055. These compounds are more potent than rapamycin, and robustly downreg ...[more]