Ontology highlight
ABSTRACT:
SUBMITTER: Martin de la Fuente L
PROVIDER: S-EPMC7320055 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Martin de la Fuente Laura L Westbom-Fremer Sofia S Arildsen Nicolai Skovbjerg NS Hartman Linda L Malander Susanne S Kannisto Päivi P Måsbäck Anna A Hedenfalk Ingrid I
Virchows Archiv : an international journal of pathology 20200124 1
The response rate to checkpoint inhibitors for women with high-grade serous carcinoma of the ovary, fallopian tube, and peritoneum (HGSC) is modest, and development of predictive biomarkers is needed. The main focus has been on tumor cell PD-L1 expression, but its assessment alone is insufficient for patient selection in most malignancies. We mapped the presence of macrophages (CD68 and CD163) and lymphocytes (CD3) located within the tumor epithelium, the cell type-specific expression of PD-L1 a ...[more]