Twelve-year clinical trajectories of multimorbidity in a population of older adults.
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ABSTRACT:
SUBMITTER: Vetrano DL
PROVIDER: S-EPMC7320143 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Twelve-year clinical trajectories of multimorbidity in a population of older adults.
Vetrano Davide L DL Roso-Llorach Albert A Fernández Sergio S Guisado-Clavero Marina M Violán Concepción C Onder Graziano G Fratiglioni Laura L Calderón-Larrañaga Amaia A Marengoni Alessandra A
Nature communications 20200626 1
Multimorbidity-the co-occurrence of multiple diseases-is associated to poor prognosis, but the scarce knowledge of its development over time hampers the effectiveness of clinical interventions. Here we identify multimorbidity clusters, trace their evolution in older adults, and detect the clinical trajectories and mortality of single individuals as they move among clusters over 12 years. By means of a fuzzy c-means cluster algorithm, we group 2931 people ≥60 years in five clinically meaningful m ...[more]
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