Immune-related long non-coding RNA signature identified prognosis and immunotherapeutic efficiency in bladder cancer (BLCA).
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ABSTRACT: Background
As bladder cancer was recognized to be immunogenic, dozens of studies have focused on immune biology of BLCA, but little is known about its relationship with the long non-coding RNAs (lncRNAs).Methods
LASSO Cox regression model was used to establish immune-related lncRNAs signature (IRLS) in BLCA. The immune infiltration landscape of BLCA was conducted via ssGSEA and immunotherapy response was calculated through TIDE algorithm.Results
A total of 82 immune-related lncRNAs were screened out according to spearman correlation analysis with the immune score (|R|?>?0.4, p?ConclusionWe have developed a novel IRLS, which have a latent prognostic value for BLCA patients and might facilitate personalized counselling for immunotherapy.
SUBMITTER: Cao R
PROVIDER: S-EPMC7320553 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Immune-related long non-coding RNA signature identified prognosis and immunotherapeutic efficiency in bladder cancer (BLCA).
Cao Rui R Yuan Lushun L Ma Bo B Wang Gang G Tian Ye Y
Cancer cell international 20200626
<h4>Background</h4>As bladder cancer was recognized to be immunogenic, dozens of studies have focused on immune biology of BLCA, but little is known about its relationship with the long non-coding RNAs (lncRNAs).<h4>Methods</h4>LASSO Cox regression model was used to establish immune-related lncRNAs signature (IRLS) in BLCA. The immune infiltration landscape of BLCA was conducted via ssGSEA and immunotherapy response was calculated through TIDE algorithm.<h4>Results</h4>A total of 82 immune-relat ...[more]
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