Ontology highlight
ABSTRACT:
SUBMITTER: Belasri K
PROVIDER: S-EPMC7321197 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20200528 11
The synthesis of new phenanthr[9,10-<i>e</i>][1,3]oxazines was achieved by the direct coupling of 9-phenanthrol with cyclic imines in the modified <i>aza</i>-Friedel-Crafts reaction followed by the ring closure of the resulting bifunctional aminophenanthrols with formaldehyde. Aminophenanthrol-type Mannich bases were synthesised and transformed to phenanthr[9,10-<i>e</i>][1,3]oxazines via [4 + 2] cycloaddition. Detailed NMR structural analyses of the new polyheterocycles as well as conformationa ...[more]