In Vivo Wound Healing and In Vitro Anti-Inflammatory Activity Evaluation of Phlomis russeliana Extract Gel Formulations.

ABSTRACT: The air-dried aerial parts of Phlomis russeliana (Sims) Lag. Ex Benth. was extracted by methanol and fractionated by n-hexane, dichloromethane, and ethyl acetate, respectively. The wound healing properties of P. russeliana extract gel was evaluated using the in vivo excisional wound model using Balb-c mice. Initially, the P. russeliana methanol extract showed LOX inhibitory activity at IC₅₀ = 23.2 µg/mL, whereas the DPPH^• assay showed IC₅₀ = 0.89 mg/mL, and the ABTS^• assay showed IC₅₀ = 0.99 mg/mL, respectively. In addition, a remarkable anti-inflammatory activity was observed in the cell culture assay. Thereafter, activity-guided fractionation was performed by LOX enzyme inhibition assays, and the structure

SUBMITTER: Okur ME 

PROVIDER: S-EPMC7321211 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature