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COVID-19 trials in Italy: A call for simplicity, top standards and global pooling.

ABSTRACT: The novel coronavirus disease, affecting ~9 million people in the past five months and causing >460,000 deaths worldwide, is completely new to mankind. More than 2,000 research projects registered at ClinTrials.gov are aiming at finding effective treatments for rapid transfer to clinical practice. Unfortunately, just few studies have a sufficiently valid design to provide reliable information for clinical practice.

SUBMITTER: Maggioni AP

PROVIDER: S-EPMC7321654 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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COVID-19 trials in Italy: A call for simplicity, top standards and global pooling.

Maggioni Aldo P AP Andreotti Felicita F Gervasoni Cristina C Di Pasquale Giuseppe G

International journal of cardiology 20200628

The novel coronavirus disease, affecting ~9 million people in the past five months and causing >460,000 deaths worldwide, is completely new to mankind. More than 2,000 research projects registered at ClinTrials.gov are aiming at finding effective treatments for rapid transfer to clinical practice. Unfortunately, just few studies have a sufficiently valid design to provide reliable information for clinical practice. ...[more]

PMID: 32610153

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Project description:This article lays out the contours of a novel approach to social change and interactions, based on the organic interplay of individuals, institutions, countries and the global society. This approach is based on the POZE paradigm, which posits that change starts inside and is nurtured from the outside in - both for individuals and for durable social change. Such a holistic perspective is crucial to build society as it emerges from the Pandemic. COVID-19 is a reminder that humans around the World are fundamentally all the same; the result of 4 dimensions - soul, heart, mind and body, which find their expression in aspirations, emotions, thoughts and sensations. These 4 dimensions constantly interact and influence each other in ways that reflect the 4-dimensional dynamic that shapes our collective existence. Individuals are the micro dimension that stands at the center of everything else. Forming part of various institutions, from families to parties, individuals are constitutive components of the meso dimension. Individuals and institutions form countries and economies, the macro-dimension. These dimensions in addition to nature and supra-national institutions form the meta-dimension. A constant interplay connects and determines what happens in each dimension and what derives from it. To thrive in the post-pandemic world, we must understand and optimize this interplay. This is the point of departure for the argumentation laid out in this article. The prevailing systemic imbalance in which many lack the means to cover their basic needs can only be addressed by planting the C-Core (completion, compassion, creativity, cooperation) at the center of human interactions. When we bring risks, responsibility and real opportunities together in one coherent framework whilst applying the proposed twice 4-dimensional paradigm-shift a set of concrete recommendations appears. Looking at individuals, and institutions, the article concludes with suggestions to seize this moment and shape not merely a response to the crises, but to lay the ground for a new social contract. In the past the C in C-Suite stood for Chief, the upper part of the leadership ladder in an institution. In the future that C must represent C-Core qualities.Supplementary informationThe online version contains supplementary material available at 10.1007/s42413-021-00110-0.

Dataset Information

COVID-19 trials in Italy: A call for simplicity, top standards and global pooling.

Publications

COVID-19 trials in Italy: A call for simplicity, top standards and global pooling.

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